Non-uniform aspects of the SARS-CoV-2 intraspecies evolution reopen question of its originArticle Published on 2022-12-012022-11-16 Journal: International journal of biological macromolecules [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, [키워드] acute respiratory syndrome beta-coronavirus Characteristics conducted conserved coronavirus disease Coronavirus-2 COVID-19 distribution Evenly-uneven Evidence Evolution Frequency functional furin cleavage Furin cleavage site (FCS) hypothese Hypothesis Invariant regions Mutation mutations pandemic Pandemics Protein question Region residue residues SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2. Support the SARS-CoV-2 Transmissibility unique variants virulence virus [DOI] 10.1016/j.ijbiomac.2022.09.184 PMC 바로가기
Epistasis-Driven Evolution of the SARS-CoV-2 Secondary StructureArticle Published on 2022-12-012022-11-16 Journal: Journal of molecular evolution [Category] COVID19(2023년), SARS, 변종, [키워드] acute respiratory syndrome arises arising base pairs Compensatory Compensatory evolution conserved coronavirus Deleterious derived allele epistasis Evolution form Frequency functional genetic background Genome highlight Hydrogen bond Hypothesis Last Modification motif Mutation natural selection pathogenicity regulate RNA SARS-CoV-2 secondary secondary structure Secondary structure. Structure target the SARS-CoV-2 UTR viral replication [DOI] 10.1007/s00239-022-10073-1 PMC 바로가기
An experimental test of the nicotinic hypothesis of COVID-19Article Published on 2022-11-012022-11-16 Journal: Proceedings of the National Academy of Sciences of [Category] COVID19(2023년), SARS, 유전자 메커니즘, [키워드] acetylcholine receptors acute respiratory syndrome binding binding competition assays cells competing complex coronavirus COVID-19 disease ectodomain effort expressed Hypothesis Infection Ligand nicotinic receptors pathophysiological mechanism peptides performed Rabies virus receptor receptors S1 domain SARS-CoV-2 SARS-CoV-2 spike protein Spike protein spike protein. suggested Symptom tested the SARS-CoV-2 unlikely virus [DOI] 10.1073/pnas.2204242119 PMC 바로가기
Seroprevalence of infection-induced SARS-CoV-2 antibodies among health care users of Northern Italy: results from two serosurveys (October-November 2019 and September-October 2021)Article Published on 2022-11-012022-11-15 Journal: International Journal of Infectious Diseases [Category] SARS, 진단, 치료기술, [키워드] 95% CI 95% confidence interval age anti-Nucleocapsid IgG antibodies antibody calculated Care circulating CIs conducted COVID-19 detect domains enzyme-linked immunosorbent enzyme-linked immunosorbent assay Gender groups Health Hypothesis IgG IgG antibody Immunoglobulin immunosorbent Italy multiplex nucleocapsid Piedmont positive test result prevalence rate proportion Receptor binding domain Result S1 and S2 S1 domain Sample SARS-CoV-2 SARS-CoV-2 antibody semiquantitative method sera Seroprevalence seroprevalence. Serosurvey Support tested the spike protein Transmission dynamics virus [DOI] 10.1016/j.ijid.2022.09.017 PMC 바로가기
Does timing matter on tocilizumab administration? Clinical, analytical and radiological outcomes in COVID-19Article Published on 2022-11-012022-11-15 Journal: European Journal of Hospital Pharmacy [Category] SARS, 진단, [키워드] 30-Day mortality Administered administration adverse event adverse events analysed Biomarker C-reactive protein clinical Clinical improvement cohorts of patient comparable complementary Complementary therapies coronavirus disease COVID-19 Critical Critical care decrease Efficacy epidemiologically group hospitalised Hypothesis inflammatory parameters knowledge lactate dehydrogenase medication Mortality onset of symptom outcome Patient patients with COVID-19 pharmacological treatment Pneumonia Primary outcome pulmonary medicine Quotient radiological radiological improvement Radiology. randomised controlled trial reductions in SaO_{2} secondary Severe COVID-19 pneumonia statistically significant difference subgroup subgroups the timing therapy Tocilizumab tocilizumab administration two group were recorded while [DOI] 10.1136/ejhpharm-2020-002669 PMC 바로가기
The interplay of post-acute COVID-19 syndrome and aging: a biological, clinical and public health approachReview article Published on 2022-11-012022-10-05 Journal: Ageing research reviews [Category] COVID19(2023년), SARS, 바이오마커, 임상, [키워드] acute phase Adults alteration approach characterized COVID-19 current develop expression hospital discharge Hypothesis Infection intrinsic Older persistence Prevalence public health reported SARS CoV-2 Support survivor susceptibility Symptom syndrome the healthy trajectory [DOI] 10.1016/j.arr.2022.101686 [Article Type] Review article
Coronavirus disease 2019 subphenotypes and differential treatment response to convalescent plasma in critically ill adults: secondary analyses of a randomized clinical trialArticle Published on 2022-11-012022-11-15 Journal: Intensive care medicine [Category] Fulltext, MERS, 바이오마커, [키워드] ABO-compatible convalescent plasma Adaptive platform trial Adults analysis assigned Biomarker Biomarkers chemokines community-acquired pneumonia convalescent plasma Convalescent plasma therapy coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patient Critically ill critically ill patients Cytokines difference effector immune responses elevated endothelial explain heterogeneous homogeneous Hypothesis immunologically immunotherapies Inflammation IQR median multifactorial organ support outcome outcomes patients Population precision medicine Prevalence Randomized randomized clinical trial RCT RCTs REMAP-CAP reported secondary analysis Subphenotypes. tested therapy treatment effect Treatment response usual care with COVID-19 [DOI] 10.1007/s00134-022-06869-w PMC 바로가기
Occurrence and distribution of azithromycin in wastewater treatment plants, seawater, and sediments of the northern part of the Persian Gulf around Bushehr port: A comparison with Pre-COVID 19 pandemicResearch article Published on 2022-11-012022-10-05 Journal: Chemosphere [Category] 변종, 치료기술, 치료제, [키워드] adjusted Antibiotic resistance Antibiotics assumed Azithromycin Bushehr collected Concentration Contamination COVID 19 COVID 19 patients disease distribution ecosystem Effect Efficiency evaluate growth Hypothesis indicated investigated less observation pandemic Persian gulf plant plants Seawater treat Treatment Variation variations Wastewater treatment plants [DOI] 10.1016/j.chemosphere.2022.135996 [Article Type] Research article
Remdesivir does not affect mitochondrial DNA copy number or deletion mutation frequency in aged male rats: A short reportArticle Published on 2022-10-262022-11-16 Journal: PLoS ONE [Category] COVID19(2023년), SARS, 변종, [키워드] Affect age Brain clinical samples coronavirus determine digital PCR DNA Effect Frequency Future hearts Hypothesis individuals inhibiting kidneys liver majority male mammals mitochondrial Mutation no effect not affect Older patients with moderate Remdesivir RNA-directed RNA polymerases rodents SARS-CoV-2 Skeletal muscle Support therapy tissue treated Treatment Viral RNA [DOI] 10.1371/journal.pone.0271850 PMC 바로가기
Interpreting global variations in the toll of COVID-19: The case for context and nuance in hypothesis generation and testingArticle Published on 2022-10-192022-11-16 Journal: Frontiers in Public Health [Category] COVID19(2023년), SARS, 변종, [키워드] affecting aggregate aggregates Analysis analyzed benefit Biomarker Biomarkers cause-specific mortality country covariate COVID COVID-19 COVID-19 pandemic database domain domains driver ecological events extension Factor Factors flexible Health health economics Health policy Hypothesis Interaction interactions Interpreting Isolation joint Lifestyle factors machine learning morbidity National obesity OLS omicron outcome outcomes pandemic Policy Population populations potential risk response SARS-CoV-2 socioeconomics statistical statistical methods. These data variant variants Variation while [DOI] 10.3389/fpubh.2022.1010011 PMC 바로가기